Maximum ' entropy ' framework ' for ' inference ' of ' cell ' population ' heterogeneity ' in ' signaling ' networks '

نویسندگان

  • Purushottam D. Dixit
  • Eugenia Lyashenko
  • Mario Niepel
  • Dennis Vitkup
چکیده

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An Introduction to Inference and Learning in Bayesian Networks

Bayesian networks (BNs) are modern tools for modeling phenomena in dynamic and static systems and are used in different subjects such as disease diagnosis, weather forecasting, decision making and clustering. A BN is a graphical-probabilistic model which represents causal relations among random variables and consists of a directed acyclic graph and a set of conditional probabilities. Structure...

متن کامل

Maximum Entropy Reconstructions of Dynamic Signaling Networks from Quantitative Proteomics Data

Advances in mass spectrometry among other technologies have allowed for quantitative, reproducible, proteome-wide measurements of levels of phosphorylation as signals propagate through complex networks in response to external stimuli under different conditions. However, computational approaches to infer elements of the signaling network strictly from the quantitative aspects of proteomics data ...

متن کامل

Evaluation of the Efficiency of the Adaptive Neuro Fuzzy Inference System (ANFIS) in the Modeling of the Ionosphere Total Electron Content Time Series Case Study: Tehran Permanent GPS Station

Global positioning system (GPS) measurements provide accurate and continuous 3-dimensional position, velocity and time data anywhere on or above the surface of the earth, anytime, and in all weather conditions. However, the predominant ranging error source for GPS signals is an ionospheric error. The ionosphere is the region of the atmosphere from about 60 km to more than 1500 km above the eart...

متن کامل

Maximum entropy modeling of metabolic networks by constraining growth-rate moments predicts coexistence of phenotypes.

In this work maximum entropy distributions in the space of steady states of metabolic networks are considered upon constraining the first and second moments of the growth rate. Coexistence of fast and slow phenotypes, with bimodal flux distributions, emerges upon considering control on the average growth (optimization) and its fluctuations (heterogeneity). This is applied to the carbon cataboli...

متن کامل

Distinct cellular states determine calcium signaling response

The heterogeneity in mammalian cells signaling response is largely a result of pre-existing cell-to-cell variability. It is unknown whether cell-to-cell variability rises from biochemical stochastic fluctuations or distinct cellular states. Here, we utilize calcium response to adenosine trisphosphate as a model for investigating the structure of heterogeneity within a population of cells and an...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017